Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0003p009 | (1) | SRF2016

Involvement of MyD88 in B-cell mediated immune response in a mouse model of LPS-induced fetal death

Plenagl Susanne , Busse Mandy , Nowak Desiree , Schumacher Anne , Zenclussen Ana Claudia

Introduction: During pregnancy, the maternal immune system has to tolerate the semi-allogenic fetus while protecting the mother and the unborn against pathogens. Subclinical infections that danger the fetus constitute a challenge for the medical system. A useful model to study mechanisms underlying infection-driven fetal death is a LPS-based mouse model. The recognition of LPS, a component of gram-negative bacteria membrane, leads to an immune answer that takes place through T...